These compounds sit in a gray zone: they are legal to sell and own for laboratory research, but they are not approved by the FDA for human use and are not dietary supplements
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Recent studies have reported the various strategies used to inhibit glutamine metabolism have discrete effects on CD8 + T cells, emphasizing that targeting the same pathway with different modes may result in conflicting metabolic and functional consequences, further highlighting the importance of understanding how glutamine precisely affects the metabolic pathways and functional dynamics of different immune cell subpopulations in TME [224]
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Addressing mechanistic uncertainties and translational barriers will be critical for harnessing its therapeutic potential and realizing effective interventions against some of the most challenging medical conditions (Table 4)
