for 3 h to reach the mid-exponential phase
We suspect that this may be an underrecognized cause for metabolic acidosis in the ICU and we would agree with the suggestion that 5-oxoproline excess should be routinely considered in the differential diagnosis for a cause for a metabolic acidosis [17].
It also operates as an essential cofactor for various enzymes and plays a pivotal role in several important metabolic functions 3,4,5 including: Biochemical foundation of P450 enzyme detoxification in the liver, lungs, kidney and intestinal epithelia Participates in converting drugs and other toxic chemicals more water-soluble for easier excretion Participating in antioxidant defence systems Protection against free radicals Primary protectant of lens, cornea, skin and retina against radiation damage Regulating and maintaining cellular redox balance Helping metabolise oestrogens and inflammatory compounds Storing and transporting nitric oxide Storing cysteine reserves Regulating the function of proteins Involvement in DNA synthesis Participating in iron and copper transfer Glutathione tends to be found in high concentrations in all cells of the human body, particularly the liver
This pronounced gradient renders GSH an effective and sensitive trigger for redox-responsive drug delivery systems
a,b Values in a row with no common superscripts differ significantly (P 0.05, Table 9)
