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In addition, if your deficiency is caused by intestinal problems (such as celiac disease or Crohns disease), the effectiveness of oral supplements may be greatly reduced because the bodys ability to absorb vitamins through the intestines has been impaired

Giulivi C, Zhang YF, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto I, et al

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Therapeutic doses used in research rarely cause clinically significant changes, but those with hypotension or taking blood pressure medications should monitor carefully