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In a preclinical melanoma model, CB-839 significantly improved the therapeutic efficacy of adoptive T-cell therapy and immune checkpoint inhibitors (anti-PD1 and anti-CTLA4), triggering a superior immune response (Varghese et al., 2021)

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ParkerJLDemeJCKolokourisDKuteyiGBigginPCLeaSMet al

The circular RNA clARS regulates the ferroptosis of HCC through the binding protein ALKBH5 [141]