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350 A global lactylome and proteome analysis profiling of a hepatitis B virus-related HCC cohort identified 9256 non-histone and 19 histone protein lactylation sites in tumors and adjacent livers, demonstrating the ubiquitous nature of lactylation in tumor biology beyond histones and transcriptional regulation

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In the retatrutide trials, the ratio of fat loss to lean loss was favorable compared to caloric restriction alone, where lean mass can represent 25-35% of total weight lost