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The researchers thought this was due to the increased synthesis of extracellular matrix molecules such as hyaluronic acid and perhaps collagen

Benowitz NL, Jacob P3, Mayan H, Denaro C (1995) Sympathomimetic effects of paraxanthine and caffeine in humans

In a different investigation, Michaelis et al

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Quantitative visual count analysis of Congo Red-stained midbrain/thalamus ( A ), frontal cortex ( B ), and hippocampal ( C ) sections from male mice showed a reduction in amyloid plaques in intranasal GHK-Cu-treated transgenic mice compared to intranasal saline-treated transgenic mice while female mice showed a reduction in the midbrain/thalamus region