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The data generated during this phase help define the dose range that may be explored in subsequent studies and contribute to understanding exposure-response relationships, pharmacokinetic behavior and safety considerations associated with the investigational compound

Estudos em animais demonstraram uma reduo significativa das complicaes ps-operatrias, especialmente das deiscncias anastomticas

[40] Endogenous vitamin B 12 becomes inactive when exposed to hydrogen cyanide and nitric oxide in cigarette smoke

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