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Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2

While the body has evolved complex antioxidant systems to neutralize these reactive species, an imbalance between free radical production and antioxidant defenses can lead to oxidative stress, a state conducive to cancer development [8]

Additionally, the inducible nitric oxide synthase (iNOS), a crucial enzyme producing Nitric oxide, is expressed in the host neutrophils and epithelial cells (34)

Ligandin: a hepatic protein which binds steroids, bilirubin, carcinogens and a number of exogenous organic anions