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Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of a non-catalytic ligandin site

This is the window that the Finkley 2005 trial captured, and the Carey/Pickart ultrasound work confirmed at the structural level: an average 28% increase in collagen density, with top responders at 51%

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Toxicity evaluations demonstrate an IC50 above 300 g/mL for joint cells and no adverse effects in 28-day in vivo studies

doi: 10.1111/jnc.14037