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Notably, a similar phenomenon was observed in neurons from patients with MS, characterized by upregulated STING expression and markedly reduced STIM1 expression, suggesting that STIM1-STING-GPX4 axis-mediated ferroptosis is closely associated with neuronal injury in human MS pathology (Woo et al., 2024)

Orphanet J Rare Dis 16 , 215 (2021)

Jefferson WN, Couse JF, Padilla-Banks E, Korach KS, Newbold RR