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The passage of metabolites such as ATP, adenosine diphosphate (ADP), pyruvate, calcium ions (Ca 2+ ), and phosphate (PO 4 ) is regulated by controlling the transport proteins

A liposome is an extremely small (1/2 the width of a human hair), multi-layered bubble (called a vesicle)

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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy