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Among neuroprotective mechanisms we review are the upregulation of autophagy and proteasomal regulation leading to reductions in protein miscoding, misfolding, and the removal of damaging protein aggregates as well as the modulation of and protection against neuroinflammation

In humans, data from SARS and Middle East respiratory syndrome also showed that neurological injury in humans is rare, strongly suggesting that, normally, the BBB provides robust neuroprotection from viral CNS invasion in most patients 30

7 New England Journal of MedicineRudman et al.: six months of GH increased lean body mass and decreased fat mass versus placebo

doi: 10.3390/ijms232213828

Phytomedicine 18(8):731738