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In contrast, exposure to an enriched environment, physical activity, and learning increase the generation of new neurons, which lead to the hypothesis that the rate of neurogenesis is constantly adapting to the needs of the hippocampal circuitry (Zhao et al., 2008)

From an experimental design perspective, the key hypothesis is not that the peptides duplicate each others effects, but rather that they might support different rate-limiting steps in repair, such as cell recruitment to the injury site, fibroblast function, extracellular matrix organization, angiogenesis, and the transition from inflammatory signaling to remodeling