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In March 2025 it will be a year since the Nice Guideline on B12 Deficiency in over 16s was published

MOTS-c is the peptide most directly tied to mitochondrial function, since it is encoded in mitochondrial DNA and signals mitochondrial stress [2][3]

Serum B12, and potentially methylmalonic acid (MMA) and homocysteine, give your clinician the data to determine whether B12 is a contributing factor or whether the mood symptoms are being driven by something else entirely

Researchers typically reconstitute the powder prior to testing

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