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Important milestones in the GHK-Cu literature include the original 1973 identification of GHK as a plasma-derived cell proliferation factor, the recognition of the copper-binding role in the late 1970s, the wound healing and collagen research of the 1980s and 1990s, the establishment of GHK-Cu as a cosmetic ingredient in the 1990s and 2000s, and the transcriptomic expansion of the research literature in the 2000s and 2010s

Greenlee, H

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It was first isolated in 1974 from the cerebral venous blood of rabbits in a sleep state by Monnier and colleagues, making it one of the earlier identified endogenous neuropeptides associated with sleep-wake cycle regulation research