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The requirement for this metabolic reprogramming in dendritic cell activity is evidenced by studies showing that inhibition of glycolysis with 2-deoxyglucose (2-DG) or knockdown of glycolytic inducers [e.g., HIF-1 and alpha enolase (ENO1)], impaired dendritic cell maturation, and subsequent T cell activation (78, 80, 82, 83)

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Each dose tier delivered roughly 3 additional percentage points of weight loss, representing a linear dose-response relationship that holds across the full tested range