It also modulates metalloproteinase (MMP) activity and their inhibitors (TIMPs), influencing not just the production of new matrix but the breakdown and remodeling of existing tissue
With respect to plasma acyl-carnitines, the individuals with schizophrenia at baseline showed significantly higher levels of C4-OH (C3-DC) and C16:1, but lower concentrations of C3, C8, C10, C10:1, C10:2, C12, C14:1-OH, C14:2, and C14:2-OH when compared with healthy controls after controlling for age, sex, body mass index (BMI), smoking, and drinking
Bonnheim NB, Wang L, Lazar AA et al (2022) The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain
higher risk profile compared to other nutrients
However, even stress can cause free radical damage