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Konturek SJ, Brzozowski T, Konturek PC, et al

Studies have shown that folate deficiency, such as exposure to the dihydrofolate reductase inhibitor methotrexate, reduces hippocampal neural stem cell proliferation and is accompanied by an increased rate of apoptosis in neonatal neurons, leading to hippocampal volume atrophy and affecting memory and cognitive function [91]

Subjective evaluation of skin properties For global evaluation, at each visit, subjects were asked to grade the overall response using a 4-point rating scale: 4 = very satisfactory, 3 = moderately satisfactory, 2 = minimally satisfactory, and 1 = not satisfactory

Does Not Contain: Gluten, corn, yeast, artificial colors and flavors

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