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However, previous reviews emphasize common mechanistic pathways such as inflammation and oxidative stress while emerging pathways particularly autophagy-related signaling are under explored

For example, basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) promote fibroblast activation, collagen synthesis, and vascularization 3 , while antimicrobial peptides (AMPs) contribute to infection control and immune modulation at wound sites 21 , 22

We included patients who were referred to Korea University Anam Hospital in Seoul, Korea for VCE between January 2012 and May 2014