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Unlike the JAK/STAT pathways mentioned above, the TGF-/suppressor of mothers against decapentaplegic (Smad) pathway may be bidirectionally regulated by STAT3-induced Th17 differentiation [38]

p Values were adjusted for multiple comparisons within each measure using the Holms step-down Bonferroni correction method

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Additional peptides with mood-relevant mechanisms Beyond the primary peptides discussed above, several additional compounds demonstrate mechanisms relevant to mental health, though their evidence bases for mood disorders specifically are less developed