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The hormone insulin plays a crucial role in promoting the uptake of glucose in adipose and muscle tissue, as well as in synthesizing glycogen in muscle and secreting triglycerides ( As illustrated in Figure 1, MetS is associated with an elevation in oxidative stress, which is the underlying cause of various complications such as atherosclerosis, hypertension, myocardial infarction, and inflammation

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(103) showed that roxadustat (HIF prolyl hydroxylase inhibitor) stabilizes HIF-1/Nrf2, reducing ferroptosis, inflammation, and fibrosis in folic acid-induced renal injury