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549,550,551,552,553 Single-cell RNA sequencing revealed a significant reduction in astrocytes in AD mice, with ferroptosis activated in astrocytes, and FTH1 in astrocytes was identified as a hub gene associated with ferroptosis

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This was correlated with a loss of synaptic plasticity the process by which neurons grow, change or develop stronger connections through activity which is a crucial part of memory and learning

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