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The FDA label also explicitly states it is not indicated for weight loss management and notes that long-term cardiovascular safety has not been established

Overall, these data point to complex modulation of ferroptosis by dexamethasone: Whereas reduced GSH availability sensitizes to ferroptosis at earlier timepoints as demonstrated previously, reduced iron availability appears to reduce ferroptosis at later timepoints

The 2.4 mg dose, which became the standard dose carried forward into phase 3 trials, produced approximately 8% to 9% weight loss in 26 weeks

11Forman HJ, Zhang H, Rinna A

Researchers are now exploring their use in the treatment of chronic insomnia, inflammation and longevity presenting exciting possibilities for health and wellness advancements