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Toremifene, which shares the stilbene scaffold with tamoxifen, is also likely to undergo aromatic ring hydroxylation to a catechol derivative (3,4-diOH metabolite), which could potentially lead to oxidative DNA damage

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However, these regimens have been plagued with long term drug toxicity leading to retarded neutrite growth, mitochondrial dysfunction, and oxidative stress 18

Families of children with autism are often searching for therapies that might improve communication and quality of life, especially when treatment options are limited, said Joshua Rothman, MD, clinical assistant professor of pediatrics at the UC San Diego School of Medicine and first author of the study

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