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In contrast, NMDAR antagonist ketamine produces rapid antidepressant effects in treatment-resistant patients [16, 204]

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The reaction of radical R with AscH results in the formation of ascorbyl radical (Asc ), considered a terminal ROS in biological systems with a very low damaging effect

Future studies should therefore expand mechanistic investigations beyond commonly reported pathways and evaluate whether reported effects reflect direct target engagement or indirect downstream responses

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