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The cadherinMerlinHippoYAP signaling axis often undergoes mutations in cancer

The triggers of activating self-reactive clones are still to be determined, but may be common infections, molecular mimicry, or inflammation signals from gut microbiota (Westall, 2006)

Cellular senescence, i.e., the aging of a particular cell type, is one hallmark of aging and has been categorized as an antagonistic mechanism

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