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As can be seen in Figure 1 , patients receiving CET demonstrated significant and large improvements across the domains of Neurocognition, Processing Speed, Cognitive Style, and Social Cognition, after two years of treatment

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In the absence of the cluster, such monothiol glutaredoxins can still be glutathionylated 26,27,29 and might (slowly) transfer the glutathione moiety to reduced cysteine residues as suggested for the AtGrxS15-dependent oxidation of reduced roGFP2 by GSSG