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Given the evidence that a pulsatile pattern of GH secretion is important for many of its physiological actions, a strategy to augment physiological pulsatile GH secretion without inducing the side-effects of supraphysiological GH doses has been studied in HIV lipodystrophy with excess VAT and decreased endogenous GH secretion (144, 145)

Furthermore, in an official statement, FDA stated that patient care should not be disrupted while these compounds are under evaluation for efficacy

Across all subtypes, antispasmodics and tricyclic antidepressants remain valuable, yet SSRIs are generally advised against

A number of factors contribute: Different manufacturers use different stabilization/packaging processes (e.g., presence of excipients, vacuum sealing, desiccants)