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These mediators directly participate in pathogen clearance and activate the expression of pro-inflammatory factors, creating a positive feedback loop with pro-inflammatory cytokines ( IL-15 , IL-10 , TNF- , CASP3 , and CASP9 ( Aquaculture is increasingly becoming a vital source of high-quality protein

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Biochimie, 220

In parallel, metformin suppresses apoptosis by reducing the Bax/Bcl-2 ratio and caspase-3 activation (Van et al., 2023