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But prostaglandins dont just cause pain they also help: Maintain vasodilation Support renal blood flow Aid in sodium excretion When you block them: Vasoconstriction increases Sodium & water retention may occur Blood pressure rises Now add beta blockers: Beta blockers lower blood pressure by: Reducing heart rate Decreasing cardiac output Suppressing renin release You now have two drugs working in opposite directions: Beta blockers trying to lower blood pressure Indomethacin promoting vasoconstriction & fluid retention Result

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Magnesium Water: Package Insert / Prescribing Info Package insert / product label Generic name: magnesium sulfate heptahydrate in water for injection Dosage form: injection, solution Drug classes: Laxatives, Minerals and electrolytes, Miscellaneous anticonvulsants J Code (medical billing code): J3475 (500 mg, injection) Medically reviewed by Drugs.com

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10.1146/annurev.nu.12.070192.001431 Annu Rev Nutr