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This model using hCMEC/D3 favored ECD, by decreasing cell proliferation, increasing caspase 3/7 levels, inducing apoptosis, increasing oxidative phosphorylation, inducing mitochondrial dysfunction, and promoting higher cell migration [115]

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The experimental techniques that were used include quantitative PCR (qPCR), liquid chromatography-mass spectroscopy (LC-MS), and spectrophotometry

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HGF mostly exerts an anti-fibrotic effect on glial scar reduction by inhibiting the synthesis of the proteoglycans produced by the activated astrocytes through the complete block of TGF-1 and TGF-2 action