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For example, using the same type of collection tubes and processing methods for all samples to minimize variability, the use quality control samples to detect and normalize any variability, to store samples at a constant and appropriate temperature and avoid temperature fluctuations, to prevent exposure to moisture and oxygen which can lead to oxidation and degradation of certain metabolites and to standardize quenching procedures and temperature for all samples, are strongly recommended

AMG 133 demonstrated significant dose-dependent weight loss in a phase 1 randomized, double-blind, placebo-controlled clinical trial involving participants with obesity, along with an acceptable safety and tolerability profile [124]

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