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doi: 10.1523/ENEURO.0208-17.2017 128

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In test-tube studies, alpha-lipoic acid has reduced markers of inflammation, including NF-kB, ICAM-1, VCAM-1, MMP-2, MMP-9, and IL-6 ( May lower heart disease risk factors Heart disease is responsible for one in four deaths in America ( Research from a combination of lab, animal, and human studies has shown that the antioxidant properties of alpha-lipoic acid may lower several heart disease risk factors

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Zonulin levels increased well before the onset of CIA 25 days post immunization (dpi) (Fig