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Future investigations should incorporate high-resolution joint-tissue single-cell transcriptomics, long-term OA models, and clinically stratified cohorts to further elucidate the diagnostic utility and mechanistic function of LPCAT3 in OA pathogenesis

*Correspondence: Chuan Xiang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Moreover, iron accumulation in activated microglia contributes to iron deposition within the CNS (51,52)

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Providers should assess patient tolerance and discontinue use if adverse reactions occur