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First, although GPER has been extensively studied in animal models (mice and rats), the phenotypes observed in these models may not fully replicate those observed in humans, thereby limiting the generalizability of the findings

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Its required for proper absorption of B12

First, a missed dose : the documented handling is to take it as soon as reasonably possible if several days remain before the next scheduled dose, otherwise skip it never double up to compensate, because two doses close together stacks the incretin effect and reliably provokes GI symptoms

Mol Plant 2: 344356 Takahashi H, Kopriva S, Giordano M, Saito K, Hell R (2011) Sulfur assimilation in photosynthetic organisms: molecular functions and regulations of transporters and assimilatory enzymes