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Excessive VEGF expression enhances neuroinflammation and promotes the formation of immature, hyperpermeable vessels, resulting in tissue injury and worsening BBB dysfunction (82).BMAL1 binds E-box elements in the VEGFA promoter to activate its transcription, which stimulates endothelial proliferation, migration, and differentiation (83)

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We hypothesized that the hepatic metabolome would be similarly characterized by increased alternative energy pathway utilization, altered redox balance and glutathione depletion, and reduced levels of ATP

65 , e12491 (2018)