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Meng J, Lv Z, Zhang Y, Wang Y, Qiao X, Sun C, et al

Research has found that long-term consumption of a high-fat diet (60% fat content) leads to a decline in protective bacterial genera such as Lactobacillus spp., Bifidobacterium spp., and Bacteroides-Prevotella spp., while the abundance of sulfate-reducing bacteria that produce hydrogen sulfide and LPS, which damage the intestinal barrier, significantly increases ( Oscillospiraceae and an increase in Rikenellaceae , both of which are associated with intestinal inflammation and metabolic diseases

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The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4

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