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The mechanism involves reduced availability of the precursor amino acids glycine and cysteine in older adults, which directly limits how much glutathione the body can synthesize

Together they provide both the signals and the cellular response needed for rapid, extensive vascularization

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This is because even when a psoriatic plaque is resolved, IL-17 and IL-22-producing cells remain in the epidermis and can be triggered into recruiting circulating T cells, producing a plaque relapse

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