albicans initiates metabolic reprogramming (e.g., suppressed glycolysis, enhanced oxidative stress resistance, and quiescent energy metabolism) in this niche to enter a dormant state, which directly mediates the formation and survival of antifungal-tolerant persister cells ( C
We tested the modified Dihexa against 200 M neomycin and observed no protection, suggesting that the current form of Dihexa has a high specificity for providing protection, likely via its specific interaction with native HGF (Figure 7)
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These botanicals or their natural components have demonstrated anti-colitis potential in vitro and/or in vivo studies, and may serve as promising alternatives or supplements for clinical drug development