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All of which can be very inflammatory to the immune system

Furthermore, most studies prioritize symptom improvement (e.g., pain reduction) as endpoints, with a pronounced lack of robust evidence demonstrating structural modification (e.g., cartilage preservation via quantitative MRI)

ROS homeostasis in cell survival and death The homeostasis of ROS within cells has a profound impact on cell fate, encompassing self-renewal, proliferation, differentiation, metabolic processes, and epigenetic landscape, all of which are affected by the oxygen environment and ultimately determine the process of cell death [212]

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5e), which provides a possible explanation for the reduced carbon flux into the TCA