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Biological Age Clocks Biological aging clocks use DNA methylation patterns and other biomarkers to estimate different dimensions of biological aging, including how old the body appears at the molecular level, how quickly aging-related changes are accumulating, and whether lifestyle or medical interventions may be changing the trajectory of aging

A common approach involves 1000 to 2000 IU every other day during the transition period

But, absent human trials, its next to impossible to know what it does in the body

When a trial is warranted, we use a methylation-aware approach: start low and titrate, define stop/go criteria, and monitor sleep and behavior

Separate ethics approval for the current study was not obtained, as it was a post hoc analysis