PTEN loss in breast cancer is associated with resistance to chemotherapy 58 and immune checkpoint-associated immunotherapy, which may be associated with the activation of the PI3K-AKT pathway, thereby affecting T-cell infiltration in tumors 60
J Biol Chem 278:13281335 Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A (2006) CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta
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however, it is originally colonized by the oropharynx and microaspirations from the gastrointestinal tract
It can upregulate and downregulate over 4,000 genes, and its copper binding properties also exert many positive effects [2]