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This mechanism involves reducing cyclic adenosine monophosphate (AMP) accumulation and preventing CREB-mediated transcription of gluconeogenic genes, leading to reduced glucose 6-phosphatase (G6pc) and phosphoenolpyruvate carboxykinase 1 (Pck1) expression (He et al., 2009

There are several signaling pathways, such as the phosphoinositide 3-kinases (PI3K)/protein kinase-B (Akt) pathway and the nuclear factor erythroid 2-related factor 2 (Nrf2)/nuclear factor kappa B (NF-B) pathway, which demonstrates a decrease in the inflammatory reaction and mediators upon activation of 7nAChRs [35, 36]

Definition of oxidative stress Oxidative metabolism primarily occurs in the mitochondria and endoplasmic reticulum of eukaryotic cells, where metabolic byproducts, such as free radicals, are generated during physiologic oxidation-reduction reactions [1]

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