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doi: 10.1016/j.pain.2013.11.013

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At a glance Drug / isotretinoin (Accutane), oral retinoid for severe nodular acne Supplement / omega-3 fatty acids (EPA + DHA), typically from fish oil or algae oil Primary interaction type / pharmacodynamic (lipid and platelet pathways), not pharmacokinetic Triglyceride effect / isotretinoin raises triglycerides in up to 44% of patients

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Be cautious around sensitive areas such as the corners of your mouth, nostrils, and eyes, as these regions may be more prone to irritation