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Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed

At the same time, the Guidelines seek to minimise disruption to patients

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Current Status and Future Directions Some commercial entities have marketed AOD9604 as a research compound or nutraceutical ingredient, though such uses exist in regulatory gray areas

PMID: 11673763