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48 IlicS.DrmicD.FranjicS.KolencD.CoricM.BrcicL.et al (2011a)

Conclusions Catalyzing the rate-limiting step of melanin synthesis, tyrosinase has become one of the most important targets for the development of hypopigmenting agents

Bioavailability is the most important factor in supplementation

The persistence of hyperglycemia in diabetes triggers a sequence of local metabolic, vascular, and neurochemical modifications, which ultimately culminate in vascular disease and microangiopathy [25]