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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

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Oxidative StressInduced Metabolic Syndrome Oxidative stress serves as the central pathological nexus in metabolic syndrome, which is characterized by abdominal obesity, insulin resistance, inflammation, high blood pressure, and blood lipid disorders [117]