This can be observed in the modulation of BCL2 family protein levels by ROS, as heightened pro-apoptotic BAX and BAK1 levels accompanied by a decrease in anti-apoptotic BCL2 and BCL2-like 1 (BCL2L1/BCL-XL) expression are observed in squamous cell carcinoma cells [114]
Gao, G., Wan, W., Zhang, S., Redden, D
Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges
Discussion Although some progress has been made in the use of traditional chemotherapeutic drugs for anticancer therapy, a series of problems, such as drug resistance, recurrence and metastasis resulting from the induction of tumor cell apoptosis, have prompted us to develop drugs that induce other modes of tumor cell death
Initial changes like improved skin hydration often appear within 2-4 weeks