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N.SunG.ValdearcosM.MarchettiP.et al (2019)

FIGURE 2 The mechanisms of SCFA action include histone deacetylase inhibition, which alters gene expression, and activation of the GPR41 and GPR43 receptors on intestinal L-cells

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These effects were tumor-cell specific: TVB-3166 suppressed anchorage-independent growth under lipid-rich culture conditions and significantly inhibited xenograft tumor growth in vivo , at concentrations aligned with its biochemical IC 50 for FASN and palmitate synthesis (255)

Shin J, Park H, Kim H, et al