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Current single-nucleus RNA-seq datasets from human AD tissue reveal distinct ferroptosis-related transcriptional programs in glial cells, including upregulation of TFRC, FTH1, SLC40A1, and ACSL4, which indicate enhanced iron turnover and lipid peroxidation susceptibility (Leng et al., 2021)

By targeting these interconnected pathways, we can develop more effective and synergistic treatments for a wide range of diseases, ultimately enhancing proteostasis resilience and improving patient outcomes

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Medications administered after AAV diagnosis and during the disease course, including glucocorticoids and immunosuppressive drugs, were also assessed